Orphan drugs are likely to cost a lot more than that. Case presentation Over a six-month period, a 56-year-old man developed a fresh pigmented lesion, 0.8 cm in diameter, over his right lateral thigh . Dermoscopy revealed a dark asymmetrical lesion with multiple colours and components. The border was connected with irregular, blunt, pigmented projections . There have been irregularly sized pigmented globules and dots that prolonged to the periphery and a prominent milky veil . Excision biopsy showed large nests of atypical melanocytes within the epidermis and upper dermis. A few of the nests had been fused jointly and were associated with lymphocytic inflammation and pigment release in to the surrounding dermis .. 5,000 rare diseases need drugs, but Europe only approves a handful each full year Only seven percent of drug applications for treating people who have rare diseases were approved in Europe between 2000 and 2004, despite the fact that there are more than 5 presently,000 conditions needing medication.Watching everything crumble is far more interesting than viewing it continue its destructive methods, of course, because those folks paying attention realize another civilization must rise up instead of this one following the collapse. Bid farewell to the fake power of institutionsIt will be nice if our future leaders remembered the significance of liberty and personal responsibility, of course. The reply to all the world’s problems, it turns out, is freedom – – independence in medicine, freedom in economics and freedom from government tyranny. Because, let’s face it: The primary cause of most these issues that are bringing down our world right now is bad federal government. It is bad federal government that authorized the GMOs. Bad government enforced the medical monopoly and allowed the pesticides to kill the honeybees.