Cunningham. ‘However, the actual fact it didn’t make the very best five surgical procedures could be attributed to increased consumer demand for minimally-invasive injectable wrinkle fillers and fighters as a fix to combat face aging.’ Minimally-invasive cosmetic methods jumped 13 % to 8 nearly.5 million procedures performed in 2005. The very best five minimally-invasive methods were Botox. , chemical peel , microdermabrasion , laser treatment , and sclerotherapy . This is the fourth consecutive year these minimally-invasive procedures have already been ranked in the very best five.Titers waned slightly at 6 months after the preliminary vaccination , although evidence for security remained during both epidemic periods. Fewer serious adverse events were observed among vaccine recipients than among placebo recipients. Overall, the side effects seen in this trial were moderate. The incidences of systemic adverse events were generally identical in the vaccine and placebo organizations, except for the rate of recurrence of fever, which was higher in the vaccine group slightly. Local reactions were limited by pain, inflammation, and swelling at the injection site in vaccine recipients.