In the quest to recognize disease-particular gene expression profiles in individuals with RA, researchers at the University of Michigan INFIRMARY turned to an ideal population: genetically identical, disease-discordant twins. The problem of Arthritis & Rheumatism highlights the results of their state-of-the-art genetic analysis July. Increasing evidence in the last several years indicates that B-lymphocytes play a central role in RA’s development. In this study, microarray evaluation was put on lymphoblastoid B cell lines from 11 pairs of monozygotic twins, all with one healthy and one RA-affected twin.But perhaps, both most bothersome of most Accutane side effects are its potential to cause severe birth defects if taken by pregnant women or ladies that became pregnant while taking the medication and the suggested link between the intake of Accutane and the adjustments in mood, severe unhappiness and suicidal thoughts. Since, Isotretinoin could be harmful to the fetus, it should not be used during pregnancy and ladies should avoid pregnancy for at least a month after the use of Accutane.