MABA compounds provide benefit over the two-molecule bronchodilator mixtures , in that MABA/ICS combinations can be developed with an acceptable size development programme. The molecule shows very favourable drug properties and safety. Almirall is likely to prioritize the finalization of the pre-clinical stage, aiming at starting scientific studies during first half of 2012. It includes significant safety features, including one hand dosing, visible dose indicator, an anti-double dosing system and an end-of-dose lock-out system to prevent use of a clear inhaler, as well as audio feedback to confirm successful dose intake.A.For the genomewide association research, we identified 294 of the patients who acquired received lithium treatment with good adherence for at least 2 years. The remainder of the individuals in the series either didn’t receive such treatment or did not have great adherence for at least 24 months. We identified genetic regions associated with a response to lithium treatment and then performed a replication check using SNPs marking these loci in an independent band of 100 individuals with bipolar I disorder . These 100 sufferers were selected from 114 patients with bipolar I disorder who were described us by personnel psychiatrists who had treated them for more than 10 years with lithium and noticed good adherence to the treatment. The remaining 14 patients were excluded because they didn’t fulfill the inclusion criteria.