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Normally, brain blood circulation responds to adjustments in blood pressure and nutrition and oxygen demands immediately. Presenter Constantino Iadecola, PhD, will discuss what happens when blood human brain and vessels cells do not communicate effectively, called neurovascular uncoupling. The brain either receives too little blood, leading to temporary lack of stroke and oxygen, or too very much blood flow, leading to hemorrhage. Dr. Iadecola will address the function of ET-1 in neurovascular uncoupling observed in hypertension and anti snoring and the potential of targeting its receptor, endothelin A, as a treatment. Related StoriesPresence of connexin proteins suppresses principal tumor growthGriffith University uncovers first 3-D picture of protein linked to cancer spreadUnique, tiny protein cage developed to deliver chemotherapy chemicals to cancer cellsThe symposium will become held Saturday directly, September 5, from 10:30 AM to 12 PM EDT in Ballroom A of the Hyatt Regency Savannah.