Study: Lowering Beta-Blocker Dose May Boost Survival After CORONARY ATTACK: – MONDAY, Sept. 21, 2015 – – People treated with low-dosage beta blockers after a coronary attack may fare much better than those provided the standard dose of the commonly prescribed medication, a new study suggests cialis online . Heart attack patients given simply one-fourth of the dosage used in clinical trials lived just as long as sufferers on an increased dose, according to experts at Northwestern University in Chicago. And in some cases, those on a low dose lived much longer even, with a 20 % to twenty five % boost in survival. To maximize effectiveness, beta-blocker dosage should probably be personalized for specific patients, the study authors advised.
Riely, M.D., Ph.D., Marileila Varella-Garcia, Ph.D., Geoffrey I. Shapiro, M.D., Ph.D., Daniel B. Costa, M.D., Ph.D., Robert C. Doebele, M.D., Ph.D., Long Phi Le, M.D., Ph.D., Zongli Zheng, Ph.D., Weiwei Tan, Ph.D., Patricia Stephenson, Sc.D., S. Martin Shreeve, M.D., Ph.D., Lesley M. Tye, Ph.D., James G. Christensen, Ph.D., Keith D. Wilner, Ph.D., Jeffrey W. Clark, M.D., and A. John Iafrate, M.D., Ph.D.5-9 Rearrangement leads to fusion of a portion of ROS1 that includes the complete tyrosine kinase domain with 1 of 12 different partner proteins.10 The resulting ROS1 fusion kinases are constitutively activated and drive cellular transformation. Whether the numerous ROS1 fusion kinases may have different oncogenic properties is normally unknown. ROS1 rearrangements take place in around 1 percent of individuals with NSCLC.11 Of the estimated 1.5 million new cases of NSCLC worldwide each full year, approximately 15,000 may be powered by oncogenic ROS1 fusions.