The most typical cause of genital ulcer disease worldwide.

C . Celum, A. Wald, J.R. Lingappa, A.S. Magaret, R.S. Wang, N. Mugo, A. Mujugira, J.M. Baeten, J.We. Mullins, J.P. Hughes, E.A. Bukusi, C.R. Cohen, E. Katabira, A. Ronald, J. Kiarie, C. Farquhar, G.J. Stewart, J. Makhema, M. Essex, E. Had been, K.H. Fife, G. De Bruyn, G.E. Gray, J.A. McIntyre, R. Manongi, S. Kapiga, D. Coetzee, S. Allen, M. Inambao, K. Kayitenkore, E. Karita, W. Kanweka, S. Delany, H. Rees, B. Vwalika, W. Stevens, M.S. Campbell, K.K. Thomas, R.W. Coombs, R. Morrow, W.L.H. Whittington, M.J. McElrath, L. Barnes, R. Ridzon, and L. Corey for the Partners in Avoidance HSV/HIV Transmission Study Team: Acyclovir and Transmitting of HIV-1 from People Infected with HIV-1 and HSV-2 The seroprevalence of herpes virus type 2 , the most typical cause of genital ulcer disease worldwide, is 60 to 90 percent in populations with human immunodeficiency virus type 1 .1 Clinical manifestations of HSV-2 range from unrecognized or mild genital symptoms generally in most people with HIV-1 infection to severe genital ulcer disease in individuals with advanced HIV-1 disease.2,3 Genital shedding of the herpes simplex virus occurs on up to 30 percent of days in people infected with HIV-1, often when they haven’t any symptoms or observable lesions.4,5 Laboratory and epidemiologic research suggest that HSV-2 may increase the infectiousness of HIV-1.

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