De Sauvage, Ph.D., and Jennifer A. Low, M.D., Ph.D.: Brief Record: Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449 Medulloblastoma is a malignant tumor of the cerebellum. The median age at diagnosis is 5 years, with the age range extending into young adulthood. Primary management consists of surgical resection followed by radiation chemotherapy and therapy. Current therapies have significant long-term and short-term undesireable effects, including postoperative mutism, neurocognitive deficits, endocrinopathies, sterility, and the chance of secondary high-grade glioma or meningioma. 1 Individuals with recurrent disease after major therapy have a poor prognosis particularly, with a median survival of significantly less than 6 months; the 2-12 months survival price among these sufferers is approximately 9 percent.2 The hedgehog pathway is an essential embryonic signaling cascade that regulates stem-cell and progenitor-cell differentiation in multiple developmental processes.3 Smoothened homologue is a transmembrane proteins that activates the downstream hedgehog signaling pathway.The study looked at more than 4,000 American adults who were assessed one, six and 12 months after suffering a heart attack. It included sufferers who were smokers at the time of their heart attack , smokers who quit before their heart attack and folks who never smoked . Forty-six % of current smokers stop smoking within a full year after their heart attacks, the researchers found. Patients who also had never smoked had the very best health by the finish of the follow-up period.