The study protocol is available with the full text of this article at NEJM.org. Additional details are given in a previous survey on the scholarly study design5 and in the Supplementary Appendix, available at NEJM.org. Statistical Evaluation An adaptive Bayesian study design allowing up to 1200 individuals to endure randomization was used, featuring sample size reestimation and two interim analyses with prespecified trial-stopping rules .In the event that you do smoke you want to consider quitting then. Not only does it increase your risk for multiple types of cancers but it can also harm all your main organs,cause your skin layer to become wrinkled, turn your tooth yellow and much more. On top of this smoking may also have a negative effect on those around you via the smoke cigarettes you exhale. Quitting is not going to become easy but if you want to reduce your overall bowel cancer risk and considerably improve your health you should give it a try. Colorectal cancer is a horrible disease that nobody must have to endure. However, by taking the precautionary measures discussed in this article you should be in a position to decrease your risk and ideally avoid this problem completely.